|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFRSF12A ORF mammalian expression plasmid, C-GFPSpark tag||RG80164-ACG|
|Rat TNFRSF12A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80164-ACR|
|Rat TNFRSF12A ORF mammalian expression plasmid, C-Flag tag||RG80164-CF|
|Rat TNFRSF12A ORF mammalian expression plasmid, C-His tag||RG80164-CH|
|Rat TNFRSF12A ORF mammalian expression plasmid, C-Myc tag||RG80164-CM|
|Rat TNFRSF12A ORF mammalian expression plasmid, C-HA tag||RG80164-CY|
|Rat TNFRSF12A Gene cDNA clone plasmid||RG80164-G|
|Rat TNFRSF12A ORF mammalian expression plasmid, N-Flag tag||RG80164-NF|
|Rat TNFRSF12A ORF mammalian expression plasmid, N-His tag||RG80164-NH|
|Rat TNFRSF12A ORF mammalian expression plasmid, N-Myc tag||RG80164-NM|
|Rat TNFRSF12A ORF mammalian expression plasmid, N-HA tag||RG80164-NY|
|Rat TNFRSF12A natural ORF mammalian expression plasmid||RG80164-UT|
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Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placenta, and kidney, at intermediate levels in lung, skeletal muscle, and pancreas, and at low levels in brain and liver. In addition, elevated FN14 expression was found in human liver cancer cell lines and hepatocellular carcinoma specimens. Expression of mouse Fn14 was upregulated in hepatocellular carcinoma nodules that develop in 2 different transgenic mouse models of hepatocarcinogenesis. TNFRSF12A is the weak inducer of apoptosis in some cell types. It promotes angiogenesis and the proliferation of endothelial cells. TNFRSF12A may modulate cellular adhesion to matrix proteins.