|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat CD70 ORF mammalian expression plasmid, C-GFPSpark tag||RG80161-ACG|
|Rat CD70 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80161-ACR|
|Rat CD70 ORF mammalian expression plasmid, C-Flag tag||RG80161-CF|
|Rat CD70 ORF mammalian expression plasmid, C-His tag||RG80161-CH|
|Rat CD70 ORF mammalian expression plasmid, C-Myc tag||RG80161-CM|
|Rat CD70 ORF mammalian expression plasmid, C-HA tag||RG80161-CY|
|Rat CD70 Gene cDNA clone plasmid||RG80161-G|
|Rat CD70 ORF mammalian expression plasmid, N-Flag tag||RG80161-NF|
|Rat CD70 ORF mammalian expression plasmid, N-His tag||RG80161-NH|
|Rat CD70 ORF mammalian expression plasmid, N-Myc tag||RG80161-NM|
|Rat CD70 ORF mammalian expression plasmid, N-HA tag||RG80161-NY|
|Rat CD70 natural ORF mammalian expression plasmid||RG80161-UT|
|Learn more about expression Vectors|
CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.