|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFRSF11A ORF mammalian expression plasmid, C-GFPSpark tag||RG80160-ACG|
|Rat TNFRSF11A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80160-ACR|
|Rat TNFRSF11A ORF mammalian expression plasmid, C-Flag tag||RG80160-CF|
|Rat TNFRSF11A ORF mammalian expression plasmid, C-His tag||RG80160-CH|
|Rat TNFRSF11A ORF mammalian expression plasmid, C-Myc tag||RG80160-CM|
|Rat TNFRSF11A ORF mammalian expression plasmid, C-HA tag||RG80160-CY|
|Rat TNFRSF11A Gene cDNA clone plasmid||RG80160-G|
|Rat TNFRSF11A ORF mammalian expression plasmid, N-Flag tag||RG80160-NF|
|Rat TNFRSF11A ORF mammalian expression plasmid, N-His tag||RG80160-NH|
|Rat TNFRSF11A ORF mammalian expression plasmid, N-Myc tag||RG80160-NM|
|Rat TNFRSF11A ORF mammalian expression plasmid, N-HA tag||RG80160-NY|
|Rat TNFRSF11A natural ORF mammalian expression plasmid||RG80160-UT|
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TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.