|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFRSF11B ORF mammalian expression plasmid, C-GFPSpark tag||RG80159-ACG|
|Rat TNFRSF11B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80159-ACR|
|Rat TNFRSF11B ORF mammalian expression plasmid, C-Flag tag||RG80159-CF|
|Rat TNFRSF11B ORF mammalian expression plasmid, C-His tag||RG80159-CH|
|Rat TNFRSF11B ORF mammalian expression plasmid, C-Myc tag||RG80159-CM|
|Rat TNFRSF11B ORF mammalian expression plasmid, C-HA tag||RG80159-CY|
|Rat TNFRSF11B Gene cDNA clone plasmid||RG80159-G|
|Rat TNFRSF11B ORF mammalian expression plasmid, N-Flag tag||RG80159-NF|
|Rat TNFRSF11B ORF mammalian expression plasmid, N-His tag||RG80159-NH|
|Rat TNFRSF11B ORF mammalian expression plasmid, N-Myc tag||RG80159-NM|
|Rat TNFRSF11B ORF mammalian expression plasmid, N-HA tag||RG80159-NY|
|Rat TNFRSF11B natural ORF mammalian expression plasmid||RG80159-UT|
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Osteoprotegerin or TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. Osteoprotegerin/TNFRSF11B acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. This protein may inhibit the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. Osteoprotegerin/TNFRSF11B also play a role in preventing arterial calcification, act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.