|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat CD2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80158-ACG|
|Rat CD2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80158-ACR|
|Rat CD2 ORF mammalian expression plasmid, C-Flag tag||RG80158-CF|
|Rat CD2 ORF mammalian expression plasmid, C-His tag||RG80158-CH|
|Rat CD2 ORF mammalian expression plasmid, C-Myc tag||RG80158-CM|
|Rat CD2 ORF mammalian expression plasmid, C-HA tag||RG80158-CY|
|Rat CD2 Gene cDNA clone plasmid||RG80158-G|
|Rat CD2 ORF mammalian expression plasmid, N-Flag tag||RG80158-NF|
|Rat CD2 ORF mammalian expression plasmid, N-His tag||RG80158-NH|
|Rat CD2 ORF mammalian expression plasmid, N-Myc tag||RG80158-NM|
|Rat CD2 ORF mammalian expression plasmid, N-HA tag||RG80158-NY|
|Rat CD2 natural ORF mammalian expression plasmid||RG80158-UT|
|Learn more about expression Vectors|
T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.