|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFRSF17 ORF mammalian expression plasmid, C-GFPSpark tag||RG80156-ACG|
|Rat TNFRSF17 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80156-ACR|
|Rat TNFRSF17 ORF mammalian expression plasmid, C-Flag tag||RG80156-CF|
|Rat TNFRSF17 ORF mammalian expression plasmid, C-His tag||RG80156-CH|
|Rat TNFRSF17 ORF mammalian expression plasmid, C-Myc tag||RG80156-CM|
|Rat TNFRSF17 ORF mammalian expression plasmid, C-HA tag||RG80156-CY|
|Rat TNFRSF17 Gene cDNA clone plasmid||RG80156-G|
|Rat TNFRSF17 ORF mammalian expression plasmid, N-Flag tag||RG80156-NF|
|Rat TNFRSF17 ORF mammalian expression plasmid, N-His tag||RG80156-NH|
|Rat TNFRSF17 ORF mammalian expression plasmid, N-Myc tag||RG80156-NM|
|Rat TNFRSF17 ORF mammalian expression plasmid, N-HA tag||RG80156-NY|
|Rat TNFRSF17 natural ORF mammalian expression plasmid||RG80156-UT|
|Learn more about expression Vectors|
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.