|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat HFE2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80142-ACG|
|Rat HFE2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80142-ACR|
|Rat HFE2 ORF mammalian expression plasmid, C-Flag tag||RG80142-CF|
|Rat HFE2 ORF mammalian expression plasmid, C-His tag||RG80142-CH|
|Rat HFE2 ORF mammalian expression plasmid, C-Myc tag||RG80142-CM|
|Rat HFE2 ORF mammalian expression plasmid, C-HA tag||RG80142-CY|
|Rat HFE2 Gene cDNA clone plasmid||RG80142-G|
|Rat HFE2 ORF mammalian expression plasmid, N-Flag tag||RG80142-NF|
|Rat HFE2 ORF mammalian expression plasmid, N-His tag||RG80142-NH|
|Rat HFE2 ORF mammalian expression plasmid, N-Myc tag||RG80142-NM|
|Rat HFE2 ORF mammalian expression plasmid, N-HA tag||RG80142-NY|
|Rat HFE2 natural ORF mammalian expression plasmid||RG80142-UT|
|Learn more about expression Vectors|
Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).