|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TGFBR2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80139-ACG|
|Rat TGFBR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80139-ACR|
|Rat TGFBR2 ORF mammalian expression plasmid, C-Flag tag||RG80139-CF|
|Rat TGFBR2 ORF mammalian expression plasmid, C-His tag||RG80139-CH|
|Rat TGFBR2 ORF mammalian expression plasmid, C-Myc tag||RG80139-CM|
|Rat TGFBR2 ORF mammalian expression plasmid, C-HA tag||RG80139-CY|
|Rat TGFBR2 Gene cDNA clone plasmid||RG80139-G|
|Rat TGFBR2 ORF mammalian expression plasmid, N-Flag tag||RG80139-NF|
|Rat TGFBR2 ORF mammalian expression plasmid, N-His tag||RG80139-NH|
|Rat TGFBR2 ORF mammalian expression plasmid, N-Myc tag||RG80139-NM|
|Rat TGFBR2 ORF mammalian expression plasmid, N-HA tag||RG80139-NY|
|Rat TGFBR2 natural ORF mammalian expression plasmid||RG80139-UT|
|Learn more about expression Vectors|
TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.