|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat VEGFC ORF mammalian expression plasmid, C-GFPSpark tag||RG80103-ACG|
|Rat VEGFC ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80103-ACR|
|Rat VEGFC ORF mammalian expression plasmid, C-Flag tag||RG80103-CF|
|Rat VEGFC ORF mammalian expression plasmid, C-His tag||RG80103-CH|
|Rat VEGFC ORF mammalian expression plasmid, C-Myc tag||RG80103-CM|
|Rat VEGFC ORF mammalian expression plasmid, C-HA tag||RG80103-CY|
|Rat VEGFC Gene cDNA clone plasmid||RG80103-G|
|Rat VEGFC ORF mammalian expression plasmid, N-Flag tag||RG80103-NF|
|Rat VEGFC ORF mammalian expression plasmid, N-His tag||RG80103-NH|
|Rat VEGFC ORF mammalian expression plasmid, N-Myc tag||RG80103-NM|
|Rat VEGFC ORF mammalian expression plasmid, N-HA tag||RG80103-NY|
|Rat VEGFC natural ORF mammalian expression plasmid||RG80103-UT|
|Learn more about expression Vectors|
Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF family. Upon biosynthesis, VEGF-C protein is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGF-C protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. VEGF-C protein is over-expressed in various human cancers including breast cancer and prostate cancer. VEGF-C/VEGFR-3 axis, through different signaling pathways, plays a critical role in cancer progression by regulating different cellular functions, such as invasion, proliferation, and resistance to chemotherapy. Thus, targeting the VEGF-C/VEGFR-3 axis may be therapeutically significant for certain types of tumors.