|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat GDNF ORF mammalian expression plasmid, C-GFPSpark tag||RG80050-ACG|
|Rat GDNF ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80050-ACR|
|Rat GDNF ORF mammalian expression plasmid, C-Flag tag||RG80050-CF|
|Rat GDNF ORF mammalian expression plasmid, C-His tag||RG80050-CH|
|Rat GDNF ORF mammalian expression plasmid, C-Myc tag||RG80050-CM|
|Rat GDNF ORF mammalian expression plasmid, C-HA tag||RG80050-CY|
|Rat GDNF Gene cDNA clone plasmid||RG80050-M|
|Rat GDNF ORF mammalian expression plasmid, N-Flag tag||RG80050-NF|
|Rat GDNF ORF mammalian expression plasmid, N-His tag||RG80050-NH|
|Rat GDNF ORF mammalian expression plasmid, N-Myc tag||RG80050-NM|
|Rat GDNF ORF mammalian expression plasmid, N-HA tag||RG80050-NY|
|Rat GDNF natural ORF mammalian expression plasmid||RG80050-UT|
|Learn more about expression Vectors|
Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.