|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat TNFα ORF mammalian expression plasmid, C-GFPSpark tag||RG80045-ACG|
|Rat TNFα ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80045-ACR|
|Rat TNFα ORF mammalian expression plasmid, C-Flag tag||RG80045-CF|
|Rat TNFα ORF mammalian expression plasmid, C-His tag||RG80045-CH|
|Rat TNFα ORF mammalian expression plasmid, C-Myc tag||RG80045-CM|
|Rat TNFα ORF mammalian expression plasmid, C-HA tag||RG80045-CY|
|Rat TNFα Gene cDNA clone plasmid||RG80045-M|
|Rat TNFα ORF mammalian expression plasmid, N-Flag tag||RG80045-NF|
|Rat TNFα ORF mammalian expression plasmid, N-His tag||RG80045-NH|
|Rat TNFα ORF mammalian expression plasmid, N-Myc tag||RG80045-NM|
|Rat TNFα ORF mammalian expression plasmid, N-HA tag||RG80045-NY|
|Rat TNFα natural ORF mammalian expression plasmid||RG80045-UT|
|Learn more about expression Vectors|
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.