|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat GHR ORF mammalian expression plasmid, C-GFPSpark tag||RG80029-ACG|
|Rat GHR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80029-ACR|
|Rat GHR ORF mammalian expression plasmid, C-Flag tag||RG80029-CF|
|Rat GHR ORF mammalian expression plasmid, C-His tag||RG80029-CH|
|Rat GHR ORF mammalian expression plasmid, C-Myc tag||RG80029-CM|
|Rat GHR ORF mammalian expression plasmid, C-HA tag||RG80029-CY|
|Rat GHR Gene cDNA clone plasmid||RG80029-M|
|Rat GHR ORF mammalian expression plasmid, N-Flag tag||RG80029-NF|
|Rat GHR ORF mammalian expression plasmid, N-His tag||RG80029-NH|
|Rat GHR ORF mammalian expression plasmid, N-Myc tag||RG80029-NM|
|Rat GHR ORF mammalian expression plasmid, N-HA tag||RG80029-NY|
|Rat GHR natural ORF mammalian expression plasmid||RG80029-UT|
|Learn more about expression Vectors|
Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.