|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Rat IL1R1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80028-ACG|
|Rat IL1R1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80028-ACR|
|Rat IL1R1 ORF mammalian expression plasmid, C-Flag tag||RG80028-CF|
|Rat IL1R1 ORF mammalian expression plasmid, C-His tag||RG80028-CH|
|Rat IL1R1 ORF mammalian expression plasmid, C-Myc tag||RG80028-CM|
|Rat IL1R1 ORF mammalian expression plasmid, C-HA tag||RG80028-CY|
|Rat IL1R1 Gene cDNA clone plasmid||RG80028-M|
|Rat IL1R1 ORF mammalian expression plasmid, N-Flag tag||RG80028-NF|
|Rat IL1R1 ORF mammalian expression plasmid, N-His tag||RG80028-NH|
|Rat IL1R1 ORF mammalian expression plasmid, N-Myc tag||RG80028-NM|
|Rat IL1R1 ORF mammalian expression plasmid, N-HA tag||RG80028-NY|
|Rat IL1R1 natural ORF mammalian expression plasmid||RG80028-UT|
|Learn more about expression Vectors|
Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.