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AK4 / Adenylate Kinase 4 / AK3L1 Antibody, Rabbit PAb, Antigen Affinity Purified

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Human AK4/AK3L1 Antibody Product Information
Immunogen:Recombinant Human AK4 / AK3L1 protein (Catalog#12406-H20B)
Clone ID:
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human AK4 / AK3L1 (rh AK4 / AK3L1; Catalog#12406-H20B; P27144-1; Ala 2-Tyr 223). AK4 / AK3L1 specific IgG was purified by Human AK4 / AK3L1 affinity chromatography.
Human AK4/AK3L1 Antibody Usage Guide
Specificity:Human AK4 / AK3L1
Application:WB, ELISA, IP

WB: 1-10 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human AK4. The detection limit for Human AK4 is approximately 0.00975 ng/well.

IP: 1-4 μg/mg of lysate

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human AK4/AK3L1 Antibody WB Application Image
AK4 / Adenylate Kinase 4 / AK3L1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Human AK4/AK3L1 Antibody IP Application Image
AK4 / Adenylate Kinase 4 / AK3L1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
Other AK4/AK3L1 Antibody Products
AK4 / Adenylate Kinase 4 / AK3L1 Background

Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.

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