|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IL1RN ORF mammalian expression plasmid, C-GFPSpark tag||MG51300-ACG|
|Mouse IL1RN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG51300-ACR|
|Mouse IL1RN ORF mammalian expression plasmid, C-Flag tag||MG51300-CF|
|Mouse IL1RN ORF mammalian expression plasmid, C-His tag||MG51300-CH|
|Mouse IL1RN ORF mammalian expression plasmid, C-Myc tag||MG51300-CM|
|Mouse IL1RN ORF mammalian expression plasmid, C-HA tag||MG51300-CY|
|Mouse IL1RN Gene cDNA clone plasmid||MG51300-G|
|Mouse IL1RN ORF mammalian expression plasmid, N-Flag tag||MG51300-NF|
|Mouse IL1RN ORF mammalian expression plasmid, N-His tag||MG51300-NH|
|Mouse IL1RN ORF mammalian expression plasmid, N-Myc tag||MG51300-NM|
|Mouse IL1RN ORF mammalian expression plasmid, N-HA tag||MG51300-NY|
|Mouse IL1RN natural ORF mammalian expression plasmid||MG51300-UT|
|Learn more about expression Vectors|
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.