|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IL17A ORF mammalian expression plasmid, C-GFPSpark tag||MG51065-ACG|
|Mouse IL17A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG51065-ACR|
|Mouse IL17A ORF mammalian expression plasmid, C-Flag tag||MG51065-CF|
|Mouse IL17A ORF mammalian expression plasmid, C-His tag||MG51065-CH|
|Mouse IL17A ORF mammalian expression plasmid, C-Myc tag||MG51065-CM|
|Mouse IL17A ORF mammalian expression plasmid, C-HA tag||MG51065-CY|
|Mouse IL17A Gene cDNA clone plasmid||MG51065-G|
|Mouse IL17A ORF mammalian expression plasmid, N-Flag tag||MG51065-NF|
|Mouse IL17A ORF mammalian expression plasmid, N-His tag||MG51065-NH|
|Mouse IL17A ORF mammalian expression plasmid, N-Myc tag||MG51065-NM|
|Mouse IL17A ORF mammalian expression plasmid, N-HA tag||MG51065-NY|
|Mouse IL17A natural ORF mammalian expression plasmid||MG51065-UT|
|Learn more about expression Vectors|
IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.