|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat IL1R2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80196-ACG|
|Rat IL1R2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80196-ACR|
|Rat IL1R2 ORF mammalian expression plasmid, C-Flag tag||RG80196-CF|
|Rat IL1R2 ORF mammalian expression plasmid, C-His tag||RG80196-CH|
|Rat IL1R2 ORF mammalian expression plasmid, C-Myc tag||RG80196-CM|
|Rat IL1R2 ORF mammalian expression plasmid, C-HA tag||RG80196-CY|
|Rat IL1R2 Gene cDNA clone plasmid||RG80196-G|
|Rat IL1R2 ORF mammalian expression plasmid, N-Flag tag||RG80196-NF|
|Rat IL1R2 ORF mammalian expression plasmid, N-His tag||RG80196-NH|
|Rat IL1R2 ORF mammalian expression plasmid, N-Myc tag||RG80196-NM|
|Rat IL1R2 ORF mammalian expression plasmid, N-HA tag||RG80196-NY|
|Rat IL1R2 natural ORF mammalian expression plasmid||RG80196-UT|
|Learn more about expression Vectors|
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.