|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse MAPK13 ORF mammalian expression plasmid, C-GFPSpark tag||MG51020-ACG|
|Mouse MAPK13 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG51020-ACR|
|Mouse MAPK13 ORF mammalian expression plasmid, N-GFPSpark tag||MG51020-ANG|
|Mouse MAPK13 ORF mammalian expression plasmid, N-OFPSpark / RFP tag||MG51020-ANR|
|Mouse MAPK13 ORF mammalian expression plasmid, C-Flag tag||MG51020-CF|
|Mouse MAPK13 ORF mammalian expression plasmid, C-His tag||MG51020-CH|
|Mouse MAPK13 ORF mammalian expression plasmid, C-Myc tag||MG51020-CM|
|Mouse MAPK13 ORF mammalian expression plasmid, C-HA tag||MG51020-CY|
|Mouse MAPK13 Gene cDNA clone plasmid||MG51020-G|
|Mouse MAPK13 ORF mammalian expression plasmid, N-Flag tag||MG51020-NF|
|Mouse MAPK13 ORF mammalian expression plasmid, N-His tag||MG51020-NH|
|Mouse MAPK13 ORF mammalian expression plasmid, N-Myc tag||MG51020-NM|
|Mouse MAPK13 ORF mammalian expression plasmid, N-HA tag||MG51020-NY|
|Mouse MAPK13 natural ORF mammalian expression plasmid||MG51020-UT|
|Learn more about expression Vectors|
The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.