|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat IL25 ORF mammalian expression plasmid, C-GFPSpark tag||RG80194-ACG|
|Rat IL25 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80194-ACR|
|Rat IL25 ORF mammalian expression plasmid, C-Flag tag||RG80194-CF|
|Rat IL25 ORF mammalian expression plasmid, C-His tag||RG80194-CH|
|Rat IL25 ORF mammalian expression plasmid, C-Myc tag||RG80194-CM|
|Rat IL25 ORF mammalian expression plasmid, C-HA tag||RG80194-CY|
|Rat IL25 Gene cDNA clone plasmid||RG80194-G|
|Rat IL25 ORF mammalian expression plasmid, N-Flag tag||RG80194-NF|
|Rat IL25 ORF mammalian expression plasmid, N-His tag||RG80194-NH|
|Rat IL25 ORF mammalian expression plasmid, N-Myc tag||RG80194-NM|
|Rat IL25 ORF mammalian expression plasmid, N-HA tag||RG80194-NY|
|Rat IL25 natural ORF mammalian expression plasmid||RG80194-UT|
|Learn more about expression Vectors|
Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.