|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat IL10RB ORF mammalian expression plasmid, C-GFPSpark tag||RG80184-ACG|
|Rat IL10RB ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80184-ACR|
|Rat IL10RB ORF mammalian expression plasmid, C-Flag tag||RG80184-CF|
|Rat IL10RB ORF mammalian expression plasmid, C-His tag||RG80184-CH|
|Rat IL10RB ORF mammalian expression plasmid, C-Myc tag||RG80184-CM|
|Rat IL10RB ORF mammalian expression plasmid, C-HA tag||RG80184-CY|
|Rat IL10RB Gene cDNA clone plasmid||RG80184-G|
|Rat IL10RB ORF mammalian expression plasmid, N-Flag tag||RG80184-NF|
|Rat IL10RB ORF mammalian expression plasmid, N-His tag||RG80184-NH|
|Rat IL10RB ORF mammalian expression plasmid, N-Myc tag||RG80184-NM|
|Rat IL10RB ORF mammalian expression plasmid, N-HA tag||RG80184-NY|
|Rat IL10RB natural ORF mammalian expression plasmid||RG80184-UT|
|Learn more about expression Vectors|
Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.