|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat LTBR ORF mammalian expression plasmid, C-GFPSpark tag||RG80178-ACG|
|Rat LTBR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80178-ACR|
|Rat LTBR ORF mammalian expression plasmid, C-Flag tag||RG80178-CF|
|Rat LTBR ORF mammalian expression plasmid, C-His tag||RG80178-CH|
|Rat LTBR ORF mammalian expression plasmid, C-Myc tag||RG80178-CM|
|Rat LTBR ORF mammalian expression plasmid, C-HA tag||RG80178-CY|
|Rat LTBR Gene cDNA clone plasmid||RG80178-G|
|Rat LTBR ORF mammalian expression plasmid, N-Flag tag||RG80178-NF|
|Rat LTBR ORF mammalian expression plasmid, N-His tag||RG80178-NH|
|Rat LTBR ORF mammalian expression plasmid, N-Myc tag||RG80178-NM|
|Rat LTBR ORF mammalian expression plasmid, N-HA tag||RG80178-NY|
|Rat LTBR natural ORF mammalian expression plasmid||RG80178-UT|
|Learn more about expression Vectors|
LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. Tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for development and organization of the secondary lymphoid organs and chemokine release.