|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse GPC3 ORF mammalian expression plasmid, C-GFPSpark tag||MG50989-ACG|
|Mouse GPC3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50989-ACR|
|Mouse GPC3 ORF mammalian expression plasmid, C-Flag tag||MG50989-CF|
|Mouse GPC3 ORF mammalian expression plasmid, C-His tag||MG50989-CH|
|Mouse GPC3 ORF mammalian expression plasmid, C-Myc tag||MG50989-CM|
|Mouse GPC3 ORF mammalian expression plasmid, C-HA tag||MG50989-CY|
|Mouse GPC3 Gene cDNA clone plasmid||MG50989-G|
|Mouse GPC3 ORF mammalian expression plasmid, N-Flag tag||MG50989-NF|
|Mouse GPC3 ORF mammalian expression plasmid, N-His tag||MG50989-NH|
|Mouse GPC3 ORF mammalian expression plasmid, N-Myc tag||MG50989-NM|
|Mouse GPC3 ORF mammalian expression plasmid, N-HA tag||MG50989-NY|
|Mouse GPC3 natural ORF mammalian expression plasmid||MG50989-UT|
|Learn more about expression Vectors|
Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.