|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CX3CL1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80163-ACG|
|Rat CX3CL1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80163-ACR|
|Rat CX3CL1 ORF mammalian expression plasmid, C-Flag tag||RG80163-CF|
|Rat CX3CL1 ORF mammalian expression plasmid, C-His tag||RG80163-CH|
|Rat CX3CL1 ORF mammalian expression plasmid, C-Myc tag||RG80163-CM|
|Rat CX3CL1 ORF mammalian expression plasmid, C-HA tag||RG80163-CY|
|Rat CX3CL1 Gene cDNA clone plasmid||RG80163-G|
|Rat CX3CL1 ORF mammalian expression plasmid, N-Flag tag||RG80163-NF|
|Rat CX3CL1 ORF mammalian expression plasmid, N-His tag||RG80163-NH|
|Rat CX3CL1 ORF mammalian expression plasmid, N-Myc tag||RG80163-NM|
|Rat CX3CL1 ORF mammalian expression plasmid, N-HA tag||RG80163-NY|
|Rat CX3CL1 natural ORF mammalian expression plasmid||RG80163-UT|
|Learn more about expression Vectors|
Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.