|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat CD2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80158-ACG|
|Rat CD2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80158-ACR|
|Rat CD2 ORF mammalian expression plasmid, C-Flag tag||RG80158-CF|
|Rat CD2 ORF mammalian expression plasmid, C-His tag||RG80158-CH|
|Rat CD2 ORF mammalian expression plasmid, C-Myc tag||RG80158-CM|
|Rat CD2 ORF mammalian expression plasmid, C-HA tag||RG80158-CY|
|Rat CD2 Gene cDNA clone plasmid||RG80158-G|
|Rat CD2 ORF mammalian expression plasmid, N-Flag tag||RG80158-NF|
|Rat CD2 ORF mammalian expression plasmid, N-His tag||RG80158-NH|
|Rat CD2 ORF mammalian expression plasmid, N-Myc tag||RG80158-NM|
|Rat CD2 ORF mammalian expression plasmid, N-HA tag||RG80158-NY|
|Rat CD2 natural ORF mammalian expression plasmid||RG80158-UT|
|Learn more about expression Vectors|
T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.