|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat LTA ORF mammalian expression plasmid, C-GFPSpark tag||RG80147-ACG|
|Rat LTA ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80147-ACR|
|Rat LTA ORF mammalian expression plasmid, C-Flag tag||RG80147-CF|
|Rat LTA ORF mammalian expression plasmid, C-His tag||RG80147-CH|
|Rat LTA ORF mammalian expression plasmid, C-Myc tag||RG80147-CM|
|Rat LTA ORF mammalian expression plasmid, C-HA tag||RG80147-CY|
|Rat LTA Gene cDNA clone plasmid||RG80147-G|
|Rat LTA ORF mammalian expression plasmid, N-Flag tag||RG80147-NF|
|Rat LTA ORF mammalian expression plasmid, N-His tag||RG80147-NH|
|Rat LTA ORF mammalian expression plasmid, N-Myc tag||RG80147-NM|
|Rat LTA ORF mammalian expression plasmid, N-HA tag||RG80147-NY|
|Rat LTA natural ORF mammalian expression plasmid||RG80147-UT|
|Learn more about expression Vectors|
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1 and TNFB, is a secreted protein which belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is a highly inducible, secreted, and exists as homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRSF3 / LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells. TNF-beta/TNFSF1/Lymphotoxin alpha forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. It mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1/Lymphotoxin alpha is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in TNF-beta/TNFSF1/Lymphotoxin alpha are a cause of susceptibility psoriatic arthritis which is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy.