|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat TGFBR2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80139-ACG|
|Rat TGFBR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80139-ACR|
|Rat TGFBR2 ORF mammalian expression plasmid, C-Flag tag||RG80139-CF|
|Rat TGFBR2 ORF mammalian expression plasmid, C-His tag||RG80139-CH|
|Rat TGFBR2 ORF mammalian expression plasmid, C-Myc tag||RG80139-CM|
|Rat TGFBR2 ORF mammalian expression plasmid, C-HA tag||RG80139-CY|
|Rat TGFBR2 Gene cDNA clone plasmid||RG80139-G|
|Rat TGFBR2 ORF mammalian expression plasmid, N-Flag tag||RG80139-NF|
|Rat TGFBR2 ORF mammalian expression plasmid, N-His tag||RG80139-NH|
|Rat TGFBR2 ORF mammalian expression plasmid, N-Myc tag||RG80139-NM|
|Rat TGFBR2 ORF mammalian expression plasmid, N-HA tag||RG80139-NY|
|Rat TGFBR2 natural ORF mammalian expression plasmid||RG80139-UT|
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TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.