|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat GFRA2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80136-ACG|
|Rat GFRA2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80136-ACR|
|Rat GFRA2 ORF mammalian expression plasmid, C-Flag tag||RG80136-CF|
|Rat GFRA2 ORF mammalian expression plasmid, C-His tag||RG80136-CH|
|Rat GFRA2 ORF mammalian expression plasmid, C-Myc tag||RG80136-CM|
|Rat GFRA2 ORF mammalian expression plasmid, C-HA tag||RG80136-CY|
|Rat GFRA2 Gene cDNA clone plasmid||RG80136-G|
|Rat GFRA2 ORF mammalian expression plasmid, N-Flag tag||RG80136-NF|
|Rat GFRA2 ORF mammalian expression plasmid, N-His tag||RG80136-NH|
|Rat GFRA2 ORF mammalian expression plasmid, N-Myc tag||RG80136-NM|
|Rat GFRA2 ORF mammalian expression plasmid, N-HA tag||RG80136-NY|
|Rat GFRA2 natural ORF mammalian expression plasmid||RG80136-UT|
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GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings.