|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat EPHB6 ORF mammalian expression plasmid, C-GFPSpark tag||RG80122-ACG|
|Rat EPHB6 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80122-ACR|
|Rat EPHB6 ORF mammalian expression plasmid, C-Flag tag||RG80122-CF|
|Rat EPHB6 ORF mammalian expression plasmid, C-His tag||RG80122-CH|
|Rat EPHB6 ORF mammalian expression plasmid, C-Myc tag||RG80122-CM|
|Rat EPHB6 ORF mammalian expression plasmid, C-HA tag||RG80122-CY|
|Rat EPHB6 Gene cDNA clone plasmid||RG80122-G|
|Rat EPHB6 ORF mammalian expression plasmid, N-Flag tag||RG80122-NF|
|Rat EPHB6 ORF mammalian expression plasmid, N-His tag||RG80122-NH|
|Rat EPHB6 ORF mammalian expression plasmid, N-Myc tag||RG80122-NM|
|Rat EPHB6 ORF mammalian expression plasmid, N-HA tag||RG80122-NY|
|Rat EPHB6 natural ORF mammalian expression plasmid||RG80122-UT|
|Learn more about expression Vectors|
Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.