|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat BMP7 ORF mammalian expression plasmid, C-GFPSpark tag||RG80120-ACG|
|Rat BMP7 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80120-ACR|
|Rat BMP7 ORF mammalian expression plasmid, C-Flag tag||RG80120-CF|
|Rat BMP7 ORF mammalian expression plasmid, C-His tag||RG80120-CH|
|Rat BMP7 ORF mammalian expression plasmid, C-Myc tag||RG80120-CM|
|Rat BMP7 ORF mammalian expression plasmid, C-HA tag||RG80120-CY|
|Rat BMP7 Gene cDNA clone plasmid||RG80120-G|
|Rat BMP7 ORF mammalian expression plasmid, N-Flag tag||RG80120-NF|
|Rat BMP7 ORF mammalian expression plasmid, N-His tag||RG80120-NH|
|Rat BMP7 ORF mammalian expression plasmid, N-Myc tag||RG80120-NM|
|Rat BMP7 ORF mammalian expression plasmid, N-HA tag||RG80120-NY|
|Rat BMP7 natural ORF mammalian expression plasmid||RG80120-UT|
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BMP-7 (Bone morphogenetic protein 7), also known as osteogenic protein 1 (OP-1), is a bone morphogenetic protein which belongs to the TGF-β superfamily. OP-1 is expressed in the brain, kidneys and bladder. BMP-7 may be involved in bone homeostasis. Osteogenic protein 1 plays a key role in the transformation of mesenchymal cells into bone and cartilage. The phosphorylation of SMAD1 and SMAD5 can be induced by BMP-7, which in turn induce transcription of numerous osteogenic genes. BMP-7 treatment can also induce all of the genetic markers of osteoblast differentiation in many cell types. The expression of BMP-7 causes ventral phenotypes while its complete inhibition creates a dorsal phenotype. Human recombinant BMP-7 protein can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma. It also functions in the treatment of tibial non-union, frequently in cases where a bone graft has failed. It is found that BMP7 has the potential for treatment of chronic kidney disease.