|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Rat TGFB2 ORF mammalian expression plasmid, C-GFPSpark tag||RG80119-ACG|
|Rat TGFB2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80119-ACR|
|Rat TGFB2 ORF mammalian expression plasmid, C-Flag tag||RG80119-CF|
|Rat TGFB2 ORF mammalian expression plasmid, C-His tag||RG80119-CH|
|Rat TGFB2 ORF mammalian expression plasmid, C-Myc tag||RG80119-CM|
|Rat TGFB2 ORF mammalian expression plasmid, C-HA tag||RG80119-CY|
|Rat TGFB2 Gene cDNA clone plasmid||RG80119-G|
|Rat TGFB2 ORF mammalian expression plasmid, N-Flag tag||RG80119-NF|
|Rat TGFB2 ORF mammalian expression plasmid, N-His tag||RG80119-NH|
|Rat TGFB2 ORF mammalian expression plasmid, N-Myc tag||RG80119-NM|
|Rat TGFB2 ORF mammalian expression plasmid, N-HA tag||RG80119-NY|
|Rat TGFB2 natural ORF mammalian expression plasmid||RG80119-UT|
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TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. In addition, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.