|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse SIRPB1A ORF mammalian expression plasmid, C-GFPSpark tag||MG50816-ACG|
|Mouse SIRPB1A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50816-ACR|
|Mouse SIRPB1A ORF mammalian expression plasmid, C-Flag tag||MG50816-CF|
|Mouse SIRPB1A ORF mammalian expression plasmid, C-His tag||MG50816-CH|
|Mouse SIRPB1A ORF mammalian expression plasmid, C-Myc tag||MG50816-CM|
|Mouse SIRPB1A ORF mammalian expression plasmid, C-HA tag||MG50816-CY|
|Mouse SIRPB1A Gene cDNA clone plasmid||MG50816-G|
|Mouse SIRPB1A ORF mammalian expression plasmid, N-Flag tag||MG50816-NF|
|Mouse SIRPB1A ORF mammalian expression plasmid, N-His tag||MG50816-NH|
|Mouse SIRPB1A ORF mammalian expression plasmid, N-Myc tag||MG50816-NM|
|Mouse SIRPB1A ORF mammalian expression plasmid, N-HA tag||MG50816-NY|
|Mouse SIRPB1A natural ORF mammalian expression plasmid||MG50816-UT|
|Learn more about expression Vectors|
SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing a 110- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.