|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse FZD5 ORF mammalian expression plasmid, C-GFPSpark tag||MG50772-ACG|
|Mouse FZD5 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50772-ACR|
|Mouse FZD5 ORF mammalian expression plasmid, C-Flag tag||MG50772-CF|
|Mouse FZD5 ORF mammalian expression plasmid, C-His tag||MG50772-CH|
|Mouse FZD5 ORF mammalian expression plasmid, C-Myc tag||MG50772-CM|
|Mouse FZD5 ORF mammalian expression plasmid, C-HA tag||MG50772-CY|
|Mouse FZD5 Gene cDNA clone plasmid||MG50772-G|
|Mouse FZD5 ORF mammalian expression plasmid, His tag||MG50772-G-H|
|Mouse FZD5 ORF mammalian expression plasmid, N-Flag tag||MG50772-NF|
|Mouse FZD5 ORF mammalian expression plasmid, N-His tag||MG50772-NH|
|Mouse FZD5 ORF mammalian expression plasmid, N-Myc tag||MG50772-NM|
|Mouse FZD5 ORF mammalian expression plasmid, N-HA tag||MG50772-NY|
|Mouse FZD5 natural ORF mammalian expression plasmid||MG50772-UT|
|Learn more about expression Vectors|
Wnt signaling is involved in a variety of embryonic development processes of nonvertebrates and vertebrates, where it determines cell motility, cell polarity, differentiation, proliferation and apoptosis, as well as formation of neural synapses. Various homologs of the Wingless protein, termed WNT factors, represent key mediators and act through a receptor complex comprised of members of the Frizzled and low density lipoprotein-related receptors (LRP). 19 WNTs, 10 Frizzled, and 2 LRP proteins have been identified. Frizzled is a family of G protein-coupled receptor proteins consisting of a divergent signal peptide, a highly conserved extracellular cysteine-rich domain (CRD), a variable-length linker region, a seven-pass transmembrane domain, and a variable-length C-terminal tail.Frizzled 5 (FZD5) is believed to be the receptor for the Wnt5A ligand, and also interactions with Wnt10B, Wnt2B, and Wnt 7A functionally. Recent studies of WNT5A/Frizzled-5 signaling have revealed an unexpected and novel role in orchestrating adaptive immunity in response to microbial stimulation. In addition, FZD5 is also implicated in the survival of mature neurons in the parafascicular nucleus of the thalamus.