|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse SELE ORF mammalian expression plasmid, C-GFPSpark tag||MG50736-ACG|
|Mouse SELE ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50736-ACR|
|Mouse SELE ORF mammalian expression plasmid, C-Flag tag||MG50736-CF|
|Mouse SELE ORF mammalian expression plasmid, C-His tag||MG50736-CH|
|Mouse SELE ORF mammalian expression plasmid, C-Myc tag||MG50736-CM|
|Mouse SELE ORF mammalian expression plasmid, C-HA tag||MG50736-CY|
|Mouse SELE Gene cDNA clone plasmid||MG50736-G|
|Mouse SELE ORF mammalian expression plasmid, N-Flag tag||MG50736-NF|
|Mouse SELE ORF mammalian expression plasmid, N-His tag||MG50736-NH|
|Mouse SELE ORF mammalian expression plasmid, N-Myc tag||MG50736-NM|
|Mouse SELE ORF mammalian expression plasmid, N-HA tag||MG50736-NY|
|Mouse SELE natural ORF mammalian expression plasmid||MG50736-UT|
|Learn more about expression Vectors|
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.