|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CD68 ORF mammalian expression plasmid, C-GFPSpark tag||MG50730-ACG|
|Mouse CD68 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50730-ACR|
|Mouse CD68 ORF mammalian expression plasmid, C-Flag tag||MG50730-CF|
|Mouse CD68 ORF mammalian expression plasmid, C-His tag||MG50730-CH|
|Mouse CD68 ORF mammalian expression plasmid, C-Myc tag||MG50730-CM|
|Mouse CD68 ORF mammalian expression plasmid, C-HA tag||MG50730-CY|
|Mouse CD68 Gene cDNA clone plasmid||MG50730-G|
|Mouse CD68 ORF mammalian expression plasmid, N-Flag tag||MG50730-NF|
|Mouse CD68 ORF mammalian expression plasmid, N-His tag||MG50730-NH|
|Mouse CD68 ORF mammalian expression plasmid, N-Myc tag||MG50730-NM|
|Mouse CD68 ORF mammalian expression plasmid, N-HA tag||MG50730-NY|
|Mouse CD68 natural ORF mammalian expression plasmid||MG50730-UT|
|Learn more about expression Vectors|
Macrosialin, also known as CD68 and Gp110, is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.