|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CD33 ORF mammalian expression plasmid, C-GFPSpark tag||MG50712-ACG|
|Mouse CD33 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50712-ACR|
|Mouse CD33 ORF mammalian expression plasmid, C-Flag tag||MG50712-CF|
|Mouse CD33 ORF mammalian expression plasmid, C-His tag||MG50712-CH|
|Mouse CD33 ORF mammalian expression plasmid, C-Myc tag||MG50712-CM|
|Mouse CD33 ORF mammalian expression plasmid, C-HA tag||MG50712-CY|
|Mouse CD33 Gene cDNA clone plasmid||MG50712-G|
|Mouse CD33 ORF mammalian expression plasmid, N-Flag tag||MG50712-NF|
|Mouse CD33 ORF mammalian expression plasmid, N-His tag||MG50712-NH|
|Mouse CD33 ORF mammalian expression plasmid, N-Myc tag||MG50712-NM|
|Mouse CD33 ORF mammalian expression plasmid, N-HA tag||MG50712-NY|
|Mouse CD33 natural ORF mammalian expression plasmid||MG50712-UT|
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Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.