|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Mouse IL1RAP ORF mammalian expression plasmid, C-GFPSpark tag||MG52657-ACG|
|Mouse IL1RAP ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG52657-ACR|
|Mouse IL1RAP ORF mammalian expression plasmid, C-Flag tag||MG52657-CF|
|Mouse IL1RAP ORF mammalian expression plasmid, C-His tag||MG52657-CH|
|Mouse IL1RAP ORF mammalian expression plasmid, C-Myc tag||MG52657-CM|
|Mouse IL1RAP ORF mammalian expression plasmid, C-HA tag||MG52657-CY|
|Mouse IL1RAP Gene cDNA clone plasmid||MG52657-G|
|Mouse IL1RAP ORF mammalian expression plasmid, N-Flag tag||MG52657-NF|
|Mouse IL1RAP ORF mammalian expression plasmid, N-His tag||MG52657-NH|
|Mouse IL1RAP ORF mammalian expression plasmid, N-Myc tag||MG52657-NM|
|Mouse IL1RAP ORF mammalian expression plasmid, N-HA tag||MG52657-NY|
|Mouse IL1RAP natural ORF mammalian expression plasmid||MG52657-UT|
|Learn more about expression Vectors|
Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.