|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IFNGR2 ORF mammalian expression plasmid, C-GFPSpark tag||MG50665-ACG|
|Mouse IFNGR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50665-ACR|
|Mouse IFNGR2 ORF mammalian expression plasmid, C-Flag tag||MG50665-CF|
|Mouse IFNGR2 ORF mammalian expression plasmid, C-His tag||MG50665-CH|
|Mouse IFNGR2 ORF mammalian expression plasmid, C-Myc tag||MG50665-CM|
|Mouse IFNGR2 ORF mammalian expression plasmid, C-HA tag||MG50665-CY|
|Mouse IFNGR2 Gene cDNA clone plasmid||MG50665-M|
|Mouse IFNGR2 ORF mammalian expression plasmid, N-Flag tag||MG50665-NF|
|Mouse IFNGR2 ORF mammalian expression plasmid, N-His tag||MG50665-NH|
|Mouse IFNGR2 ORF mammalian expression plasmid, N-Myc tag||MG50665-NM|
|Mouse IFNGR2 ORF mammalian expression plasmid, N-HA tag||MG50665-NY|
|Mouse IFNGR2 natural ORF mammalian expression plasmid||MG50665-UT|
|Learn more about expression Vectors|
Interferon gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNGR1), and is a new Bax suppressor. The C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. IFNGR2 has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of transcription 1 (STAT1) pathway.