|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse SLAMF8 ORF mammalian expression plasmid, C-GFPSpark tag||MG50623-ACG|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50623-ACR|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-Flag tag||MG50623-CF|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-His tag||MG50623-CH|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-Myc tag||MG50623-CM|
|Mouse SLAMF8 ORF mammalian expression plasmid, C-HA tag||MG50623-CY|
|Mouse SLAMF8 Gene cDNA clone plasmid||MG50623-M|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-Flag tag||MG50623-NF|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-His tag||MG50623-NH|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-Myc tag||MG50623-NM|
|Mouse SLAMF8 ORF mammalian expression plasmid, N-HA tag||MG50623-NY|
|Mouse SLAMF8 natural ORF mammalian expression plasmid||MG50623-UT|
|Learn more about expression Vectors|
The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.