|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat PTN ORF mammalian expression plasmid, C-GFPSpark tag||RG81121-ACG|
|Rat PTN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG81121-ACR|
|Rat PTN ORF mammalian expression plasmid, C-Flag tag||RG81121-CF|
|Rat PTN ORF mammalian expression plasmid, C-His tag||RG81121-CH|
|Rat PTN ORF mammalian expression plasmid, C-Myc tag||RG81121-CM|
|Rat PTN ORF mammalian expression plasmid, C-HA tag||RG81121-CY|
|Rat PTN ORF mammalian expression plasmid, N-Flag tag||RG81121-NF|
|Rat PTN ORF mammalian expression plasmid, N-His tag||RG81121-NH|
|Rat PTN ORF mammalian expression plasmid, N-Myc tag||RG81121-NM|
|Rat PTN ORF mammalian expression plasmid, N-HA tag||RG81121-NY|
|Rat PTN Gene cDNA clone plasmid||RG81121-U|
|Rat PTN natural ORF mammalian expression plasmid||RG81121-UT|
|Learn more about expression Vectors|
HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.