|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse ARMETL1 ORF mammalian expression plasmid, C-GFPSpark tag||MG50569-ACG|
|Mouse ARMETL1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50569-ACR|
|Mouse ARMETL1 ORF mammalian expression plasmid, C-Flag tag||MG50569-CF|
|Mouse ARMETL1 ORF mammalian expression plasmid, C-His tag||MG50569-CH|
|Mouse ARMETL1 ORF mammalian expression plasmid, C-Myc tag||MG50569-CM|
|Mouse ARMETL1 ORF mammalian expression plasmid, C-HA tag||MG50569-CY|
|Mouse ARMETL1 Gene cDNA clone plasmid||MG50569-M|
|Mouse ARMETL1 ORF mammalian expression plasmid, N-Flag tag||MG50569-NF|
|Mouse ARMETL1 ORF mammalian expression plasmid, N-His tag||MG50569-NH|
|Mouse ARMETL1 ORF mammalian expression plasmid, N-Myc tag||MG50569-NM|
|Mouse ARMETL1 ORF mammalian expression plasmid, N-HA tag||MG50569-NY|
|Mouse ARMETL1 natural ORF mammalian expression plasmid||MG50569-UT|
|Learn more about expression Vectors|
Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.