|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse IL18BP ORF mammalian expression plasmid, C-GFPSpark tag||MG50206-ACG|
|Mouse IL18BP ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50206-ACR|
|Mouse IL18BP ORF mammalian expression plasmid, C-Flag tag||MG50206-CF|
|Mouse IL18BP ORF mammalian expression plasmid, C-His tag||MG50206-CH|
|Mouse IL18BP ORF mammalian expression plasmid, C-Myc tag||MG50206-CM|
|Mouse IL18BP ORF mammalian expression plasmid, C-HA tag||MG50206-CY|
|Mouse IL18BP Gene cDNA clone plasmid||MG50206-M|
|Mouse IL18BP ORF mammalian expression plasmid, N-Flag tag||MG50206-NF|
|Mouse IL18BP ORF mammalian expression plasmid, N-His tag||MG50206-NH|
|Mouse IL18BP ORF mammalian expression plasmid, N-Myc tag||MG50206-NM|
|Mouse IL18BP ORF mammalian expression plasmid, N-HA tag||MG50206-NY|
|Mouse IL18BP natural ORF mammalian expression plasmid||MG50206-UT|
|Learn more about expression Vectors|
Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.