|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse FGFR4 ORF mammalian expression plasmid, C-GFPSpark tag||MG50194-ACG|
|Mouse FGFR4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50194-ACR|
|Mouse FGFR4 ORF mammalian expression plasmid, C-Flag tag||MG50194-CF|
|Mouse FGFR4 ORF mammalian expression plasmid, C-His tag||MG50194-CH|
|Mouse FGFR4 ORF mammalian expression plasmid, C-Myc tag||MG50194-CM|
|Mouse FGFR4 ORF mammalian expression plasmid, C-HA tag||MG50194-CY|
|Mouse FGFR4 Gene cDNA clone plasmid||MG50194-M|
|Mouse FGFR4 ORF mammalian expression plasmid, N-Flag tag||MG50194-NF|
|Mouse FGFR4 ORF mammalian expression plasmid, N-His tag||MG50194-NH|
|Mouse FGFR4 ORF mammalian expression plasmid, N-Myc tag||MG50194-NM|
|Mouse FGFR4 ORF mammalian expression plasmid, N-HA tag||MG50194-NY|
|Mouse FGFR4 natural ORF mammalian expression plasmid||MG50194-UT|
|Learn more about expression Vectors|
Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.