|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse B7-H2 ORF mammalian expression plasmid, C-GFPSpark tag||MG50190-ACG|
|Mouse B7-H2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50190-ACR|
|Mouse B7-H2 ORF mammalian expression plasmid, C-Flag tag||MG50190-CF|
|Mouse B7-H2 ORF mammalian expression plasmid, C-His tag||MG50190-CH|
|Mouse B7-H2 ORF mammalian expression plasmid, C-Myc tag||MG50190-CM|
|Mouse B7-H2 ORF mammalian expression plasmid, C-HA tag||MG50190-CY|
|Mouse B7-H2 Gene cDNA clone plasmid||MG50190-M|
|Mouse B7-H2 ORF mammalian expression plasmid, N-Flag tag||MG50190-NF|
|Mouse B7-H2 ORF mammalian expression plasmid, N-His tag||MG50190-NH|
|Mouse B7-H2 ORF mammalian expression plasmid, N-Myc tag||MG50190-NM|
|Mouse B7-H2 ORF mammalian expression plasmid, N-HA tag||MG50190-NY|
|Mouse B7-H2 natural ORF mammalian expression plasmid||MG50190-UT|
|Learn more about expression Vectors|
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.