|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat CTHRC1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80712-ACG|
|Rat CTHRC1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80712-ACR|
|Rat CTHRC1 ORF mammalian expression plasmid, C-Flag tag||RG80712-CF|
|Rat CTHRC1 ORF mammalian expression plasmid, C-His tag||RG80712-CH|
|Rat CTHRC1 ORF mammalian expression plasmid, C-Myc tag||RG80712-CM|
|Rat CTHRC1 ORF mammalian expression plasmid, C-HA tag||RG80712-CY|
|Rat CTHRC1 ORF mammalian expression plasmid, N-Flag tag||RG80712-NF|
|Rat CTHRC1 ORF mammalian expression plasmid, N-His tag||RG80712-NH|
|Rat CTHRC1 ORF mammalian expression plasmid, N-Myc tag||RG80712-NM|
|Rat CTHRC1 ORF mammalian expression plasmid, N-HA tag||RG80712-NY|
|Rat CTHRC1 Gene cDNA clone plasmid||RG80712-U|
|Rat CTHRC1 natural ORF mammalian expression plasmid||RG80712-UT|
|Learn more about expression Vectors|
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.