|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Mouse CXCL13 ORF mammalian expression plasmid, C-GFPSpark tag||MG50140-ACG|
|Mouse CXCL13 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50140-ACR|
|Mouse CXCL13 ORF mammalian expression plasmid, C-Flag tag||MG50140-CF|
|Mouse CXCL13 ORF mammalian expression plasmid, C-His tag||MG50140-CH|
|Mouse CXCL13 ORF mammalian expression plasmid, C-Myc tag||MG50140-CM|
|Mouse CXCL13 ORF mammalian expression plasmid, C-HA tag||MG50140-CY|
|Mouse CXCL13 Gene cDNA clone plasmid||MG50140-M|
|Mouse CXCL13 ORF mammalian expression plasmid, N-Flag tag||MG50140-NF|
|Mouse CXCL13 ORF mammalian expression plasmid, N-His tag||MG50140-NH|
|Mouse CXCL13 ORF mammalian expression plasmid, N-Myc tag||MG50140-NM|
|Mouse CXCL13 ORF mammalian expression plasmid, N-HA tag||MG50140-NY|
|Mouse CXCL13 natural ORF mammalian expression plasmid||MG50140-UT|
|Learn more about expression Vectors|
The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), which belongs to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. It involves in B-cell compartmental homing within secondary lymphoid organs and recently implicated in the pathogenesis of inflammatory and malignant lymphocyte-mediated diseases. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell. CXCL13 expression may also provide an additional useful tool for the diagnosis of Angioimmunoblastic T-cell lymphoma (AITL).