|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat DCN ORF mammalian expression plasmid, C-GFPSpark tag||RG80656-ACG|
|Rat DCN ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80656-ACR|
|Rat DCN ORF mammalian expression plasmid, C-Flag tag||RG80656-CF|
|Rat DCN ORF mammalian expression plasmid, C-His tag||RG80656-CH|
|Rat DCN ORF mammalian expression plasmid, C-Myc tag||RG80656-CM|
|Rat DCN ORF mammalian expression plasmid, C-HA tag||RG80656-CY|
|Rat DCN ORF mammalian expression plasmid, N-Flag tag||RG80656-NF|
|Rat DCN ORF mammalian expression plasmid, N-His tag||RG80656-NH|
|Rat DCN ORF mammalian expression plasmid, N-Myc tag||RG80656-NM|
|Rat DCN ORF mammalian expression plasmid, N-HA tag||RG80656-NY|
|Rat DCN Gene cDNA clone plasmid||RG80656-U|
|Rat DCN natural ORF mammalian expression plasmid||RG80656-UT|
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Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.