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Human Tryptophan Hydroxylase 1 / TPH1 Protein (His Tag)

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Human TPH1 Protein Product Information
Synonym:MGC119994, TPRH, TRPH
Protein Construction:A DNA sequence encoding the human TPH1 (P17752-1) (Ile 2-Ile 444) was expressed, with a polyhistide tag at the N-terminus.
Expressed Host:E. coli
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Human TPH1 Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Endotoxin:Please contact us for more information.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Met
Molecule Mass:The recombinant human TPH1 consisting of 458 amino acids and has a calculated molecular mass of 52.7 kDa. It migrates as an approximately 48 kDa band in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile 20mM Tris, 200mM NaCl, 10% glycerol, pH 8.0
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Human TPH1 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Human TPH1 Protein SDS-PAGE
Human Tryptophan Hydroxylase 1 / TPH1 Protein (His Tag) SDS-PAGE
Other TPH1 Recombinant Protein Products
Tryptophan Hydroxylase 1/TPH1 Background

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

Human Tryptophan Hydroxylase 1/TPH1 References
  • Antonia S. New, et al.,1998, American Journal of Medical Genetics Part B. 81 (1): 13-17.
  • Y. C Wang, et al.,2001, Neuropsychobiology. 43 (1): 1 - 4.
  • Diego J. et al., 2003, Science. 299 (5603): 76.
  • Allen NC, et al.,2008, Nat Genet. 40 (7): 827-34.
  • Galfalvy,H. et al., 2009, J Affect Disord. 115 (3):331-8.
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    Catalog: 11931-H07E-20
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