|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat IL17A ORF mammalian expression plasmid, C-GFPSpark tag||RG80461-ACG|
|Rat IL17A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80461-ACR|
|Rat IL17A ORF mammalian expression plasmid, C-Flag tag||RG80461-CF|
|Rat IL17A ORF mammalian expression plasmid, C-His tag||RG80461-CH|
|Rat IL17A ORF mammalian expression plasmid, C-Myc tag||RG80461-CM|
|Rat IL17A ORF mammalian expression plasmid, C-HA tag||RG80461-CY|
|Rat IL17A Gene cDNA clone plasmid||RG80461-G|
|Rat IL17A ORF mammalian expression plasmid, N-Flag tag||RG80461-NF|
|Rat IL17A ORF mammalian expression plasmid, N-His tag||RG80461-NH|
|Rat IL17A ORF mammalian expression plasmid, N-Myc tag||RG80461-NM|
|Rat IL17A ORF mammalian expression plasmid, N-HA tag||RG80461-NY|
|Rat IL17A natural ORF mammalian expression plasmid||RG80461-UT|
|Learn more about expression Vectors|
IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.