|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat PDCD1 ORF mammalian expression plasmid, C-GFPSpark tag||RG80448-ACG|
|Rat PDCD1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80448-ACR|
|Rat PDCD1 ORF mammalian expression plasmid, C-Flag tag||RG80448-CF|
|Rat PDCD1 ORF mammalian expression plasmid, C-His tag||RG80448-CH|
|Rat PDCD1 ORF mammalian expression plasmid, C-Myc tag||RG80448-CM|
|Rat PDCD1 ORF mammalian expression plasmid, C-HA tag||RG80448-CY|
|Rat PDCD1 Gene cDNA clone plasmid||RG80448-G|
|Rat PDCD1 ORF mammalian expression plasmid, N-Flag tag||RG80448-NF|
|Rat PDCD1 ORF mammalian expression plasmid, N-His tag||RG80448-NH|
|Rat PDCD1 ORF mammalian expression plasmid, N-Myc tag||RG80448-NM|
|Rat PDCD1 ORF mammalian expression plasmid, N-HA tag||RG80448-NY|
|Rat PDCD1 natural ORF mammalian expression plasmid||RG80448-UT|
|Learn more about expression Vectors|
Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.