|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Rat IL12B ORF mammalian expression plasmid, C-GFPSpark tag||RG80352-ACG|
|Rat IL12B ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80352-ACR|
|Rat IL12B ORF mammalian expression plasmid, C-Flag tag||RG80352-CF|
|Rat IL12B ORF mammalian expression plasmid, C-His tag||RG80352-CH|
|Rat IL12B ORF mammalian expression plasmid, C-Myc tag||RG80352-CM|
|Rat IL12B ORF mammalian expression plasmid, C-HA tag||RG80352-CY|
|Rat IL12B Gene cDNA clone plasmid||RG80352-G|
|Rat IL12B ORF mammalian expression plasmid, N-Flag tag||RG80352-NF|
|Rat IL12B ORF mammalian expression plasmid, N-His tag||RG80352-NH|
|Rat IL12B ORF mammalian expression plasmid, N-Myc tag||RG80352-NM|
|Rat IL12B ORF mammalian expression plasmid, N-HA tag||RG80352-NY|
|Rat IL12B natural ORF mammalian expression plasmid||RG80352-UT|
|Learn more about expression Vectors|
Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity.